Risk factors for actinic cheilitis: A meta-analysis

Rodriguez-Archilla, Alberto and Irfan-Bhatti, Amna (2021) Risk factors for actinic cheilitis: A meta-analysis. Journal of Dental Research, Dental Clinics, Dental Prospects, 15 (4). pp. 285-289. ISSN 2008-210X

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Abstract

Background. Actinic cheilitis (AC) is a potentially malignant disorder characterized by chronic lip inflammation, especially the lower lip, associated with accumulative exposure to solar radiation. The present study aimed to assess the possible risk factors related to AC.

Methods. A search for studies on AC risk factors was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Google Scholar. For dichotomous outcomes, the estimates of the effects of intervention were expressed as odds ratios (ORs) using Mantel-Haenszel (M-H) method, and for continuous outcomes, the estimates of the effects of intervention were expressed as mean difference (MD) using the inverse variance (IV) method, both with 95% confidence intervals.

Results. Twelve studies were considered in this meta-analysis. The factors from the highest to lowest risk of AC were having a low skin phototype (OR: 3.30), age >50 years (OR: 3.01), having high sun exposure, cumulative throughout life (OR: 2.13) as daily (OR: 2.00), being male (OR: 1.78), and being a drinker (OR: 1.56) or smoker (OR: 1.32). However, the use of sunscreen creams and caps/hats to protect against the sun were factors with no significant influence on the AC risk.

Conclusion. Chronic sun exposure in subjects with low skin phototypes is the main risk factor for AC.

Item Type: Article
Subjects: STM Digital Press > Medical Science
Depositing User: Unnamed user with email support@stmdigipress.com
Date Deposited: 25 May 2023 12:07
Last Modified: 19 Sep 2024 09:32
URI: http://publications.articalerewriter.com/id/eprint/917

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