Effect of Magnesium Sulphate Nebulization on the Incidence of Postoperative Sore Throat in Patients Requiring Endotracheal Intubation for General Anesthesia

Background: Post-operative sore throat (POST) is one of the most common anesthesia related complication. It is one of the undesirable post-operative events. Several Non pharmacological and pharmacological methods tried to reduce POST. we planned to study the efficacy of magnsesium sulphate nebulization in reduction of post operative sore throat.

Study Design: Prospective, comparative observational study.

Place and Duration of Study: Department of anesthesiology, AVBRH, from June 2020 to November 2020.

Materials and Methods: observational study of 60 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery of approximately 2 h or more duration requiring tracheal intubation. Patients in Group N were nebulized with 3 ml of normal saline and the patients in Group M were nebulized with 3 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min. The incidence of POST at rest and on swallowing at 0, 2, 4,12 and 24 h in the postoperative period were evaluated.

Results: No significant difference in postoperative sorethroat was observed on swallowing in between magnesium sulphate and normal saline at zero and 2nd hour. significant difference was observed at 4th,12th and 24th hour between magnesium sulphate and normal saline in reducing the incidence of post-operative sore throat.

Conclusion: MgSO4 significantly reduces the incidence of POST compared to normal saline.