Douillard, Venceslas and Castelli, Erick C. and Mack, Steven J. and Hollenbach, Jill A. and Gourraud, Pierre-Antoine and Vince, Nicolas and Limou, Sophie (2021) Current HLA Investigations on SARS-CoV-2 and Perspectives. Frontiers in Genetics, 12. ISSN 1664-8021
pubmed-zip/versions/3/package-entries/fgene-12-774922-r2/fgene-12-774922.pdf - Published Version
Download (798kB)
Abstract
The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.
Item Type: | Article |
---|---|
Subjects: | STM Digital Press > Medical Science |
Depositing User: | Unnamed user with email support@stmdigipress.com |
Date Deposited: | 20 Jan 2023 08:46 |
Last Modified: | 25 May 2024 09:13 |
URI: | http://publications.articalerewriter.com/id/eprint/65 |