Editorial: Neuroinflammation and affective/cognitive impairment: The role of white matter and glial cells

In recent years, neuroinflammatory changes have been increasingly recognized as potential mediators of a wide range of neurological diseases, including cerebrovascular diseases (Shi et al., 2019; Jurcau and Simion, 2021), depression (Jia et al., 2021), multiple sclerosis (Voet et al., 2019), Alzheimer's disease (Calsolaro and Edison, 2016; Mangalmurti and Lukens, 2022), and Parkinson's disease (PD) (Badanjak et al., 2021). Neuroinflammation occurs before visible structural damage to the brain appears. Given the high complexity of the aging process and various mechanisms contributing to cognition/emotion-related diseases, it is arduous to pinpoint any single factor. This Research Topic in Frontiers in Aging Neuroscience has produced a highly informative collection of six original research articles and one review, comprehensively covering neuroinflammation and novel interventions in rescuing affective or cognitive impairments.