Fenugreek Oil and Metformin Improve Insulin Resistance via Increase of GLUT4 and PPARγ in Metabolic Syndrome‐induced Rats

Zayed, Eman Adel and AinShoka, Afaf A. and Shazly, Kamal A. El and El-Mosallamy, Aliaa E. M. K. and Zayed, Ahmed Adel and Latif, Hekma A. Abd El (2021) Fenugreek Oil and Metformin Improve Insulin Resistance via Increase of GLUT4 and PPARγ in Metabolic Syndrome‐induced Rats. Asian Journal of Research and Reports in Endocrinology, 4 (1). pp. 29-39.

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Abstract

Background: Fructose consumption and desserts sweetened with fructose increase risk of metabolic syndrome (MS). Features of MS include insulin resistance, dyslipidemia, visceral obesity, and hypertension. The aim of this study was to evaluate the role of fenugreek oil and metformin in ameliorating features of MS.

Methods: MS was induced in rats by high‐fructose high‐fat fed diet for 8 weeks. They were randomly divided into five groups: normal control, MS control group treated with saline, MS groups given fenugreek oil (4 ml/kg), or metformin (100 mg/kg) daily for 4 weeks. Body weight, relative organ weight, glucose, insulin, adiponectin, and lipid profiles were estimated. Also glucose transporter 4 (GLUT-4) content and peroxisome proliferator‐activated receptor‐gamma (PPAR-γ) protein expressions were determined.

Results: fenugreek oil and metformin caused decrease in both MS‐induced increase in body weight and glucose. They reduced insulin level and resistance with increased adiponectin, and correction of MS‐induced hyperlipidemia. Treatment also increased GLUT-4 and PPAR-γ protein expression compared with MS control group.

Conclusion: Fenugreek oil and metformin improve features of MS via increased GLUT4 and PPARγ expression.

Item Type: Article
Subjects: STM Digital Press > Medical Science
Depositing User: Unnamed user with email support@stmdigipress.com
Date Deposited: 14 Feb 2023 10:17
Last Modified: 21 May 2024 13:31
URI: http://publications.articalerewriter.com/id/eprint/234

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