EVALUATION OF THE TOXIC EFFECTS OF DIFENOCONAZOLE FUNGICIDE (SCORE) ON MALE ALBINO RATS

This study was designed to estimate the LD50 of Score (difenoconazole) fungicide and evaluate its toxic effects on body weight, liver weight, some biochemical parameters and hematological profiles of male albino rats after chronic oral daily doses (1/20, 1/10 and 1/5 LD.50) for 8 weeks.
Rats were divided into 4 groups, the first group (G1) as control group, the other groups (G2, G3 and G4) treated daily with 20,40 and 80 mg/100 g.b.w. for 1, 4 and 8 weeks respectively
The medium lethal dose (LD.50) of Score was 400 mg /100g. body weight of adult male rat. Significant decreases in body weight, serum total protein, albumin, globulin, liver DNA and liver RNA, RBCs count, hemoglobin and blood Platelets count
However, significantly increase observed in hepatosomatic index, serum enzymes (ALAT, ASAT, ALP and CK), cholesterol, triglyceride, total lipids, serum creatinine and serum bilirubin and WBC's count