Das, Arnab and Ghosal, Subhasish and Chakraborty, Indrani and Pradhan, Nirmal (2015) Haematinic Potential of Jussiaea repens L – A Search for Antianaemic Herb. British Journal of Pharmaceutical Research, 8 (5). pp. 1-11. ISSN 22312919
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Abstract
Background: Anaemia is a common nutritional disorder. Different harmful synthetic drugs are used to combat it. So herbal remediation is in demand.
Aims: In this study a common medicinal herb Jussiaea repens (JR) was used. It is traditionally used to prevent diabetes, diuretics, fever, cough etc. But no report yet is available on anaemia prevention.
Methodology: 30 adult male albino rats were grouped as control (n=6), 2,4-DNPH induced anaemia (2 mg/100 gm body weight/day i.p.,n=18) and JR treatment (20 mg/100 gm body weight/day orally, n=6). After 7 days, 6 anaemic animals were killed, 6 kept as DNPH withdrawal and other 6 as JR supplement followed by 2,4-DNPH withdrawal. All animals were maintained till 21st day of treatment.
Results: Body growth rate was significantly (P<0.001) decreased in 2,4-DNPH induced anaemic group which was partially recovered in withdrawal and JR supplement. Liver weight was significantly decreased (P<0.01) in anaemic group than control but was significantly increased (P<0.01) in JR treatment. Spleen weight was significantly increased (P<0.05) in anaemic group but significantly decreased (P<0.05) in JR supplement and treatment. Significant decrease (P<0.05) in adrenal weight was found after 2,4-DNPH withdrawal, where other organs remain unchanged. The anaemic group showed insignificant reduction in total erythrocyte count and significant reduction (P<0.05) in haemoglobin concentration than control and were significantly recovered (P<0.05) after JR supplementation and treatment. PCV was significantly higher in withdrawal (P<0.05) and JR treatment (P<0.01) than anaemic group, where MCHC was significantly higher (P<0.01) only in JR treatment. But no remarkable change observed in MCH and total leukocyte count. Free haemoglobin in plasma showed significant rise (P<0.005) in anaemic group, but was significantly reduced alike MCV after 2,4-DNPH withdrawal, JR supplementation and treatment, which supported higher osmotic fragility of RBC in anaemic group. SEM observation of erythrocyte morphology also supported it.
Conclusion: So, crude ethanolic extract of JR can prevent anaemia and can be used further as potent antianaemic drug.
Item Type: | Article |
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Subjects: | STM Digital Press > Medical Science |
Depositing User: | Unnamed user with email support@stmdigipress.com |
Date Deposited: | 07 Jul 2023 04:09 |
Last Modified: | 12 Sep 2024 04:36 |
URI: | http://publications.articalerewriter.com/id/eprint/1111 |