Preparation and Evaluation of Matrix Tablet of Metronidazole Using Carnauba Wax

Arhewoh, Matthew and Eraga, Sylvester and Avbunudiogba, John and Fregene, Queen and Okah, Paul (2015) Preparation and Evaluation of Matrix Tablet of Metronidazole Using Carnauba Wax. British Journal of Pharmaceutical Research, 8 (5). pp. 1-8. ISSN 22312919

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Abstract

Aim: To formulate a sustained release tablet dosage form of metronidazole using carnauba wax as matrix former and binder.

Methods: Batches of metronidazole tablets were formulated by using a combination of melt and wet granulation techniques. The formulated granules were evaluated for their flow properties, while the tablets for their friability, hardness, disintegration time and metronidazole release rate. The effect of varying concentrations of carnauba wax on the formulation was ascertained and compared with a conventional commercial product.

Results: The tablets had friability and hardness values ranging from 0.87-2.98% and 6.66 to 8.08 kp, respectively. Tablet weights did not vary significantly but the disintegration time varied from 2.61 to 4.86 min and the optimal batch of tablets released about 60% of its drug within 2 h as against that of the conventional tablet with a 100% release.

Conclusion: Carnauba wax can serve as a suitable binder to formulate a sustained release metronidazole tablets to achieve a reduction in the frequency of administration and consequently enhance compliance.

Item Type: Article
Subjects: STM Digital Press > Medical Science
Depositing User: Unnamed user with email support@stmdigipress.com
Date Deposited: 10 Jun 2023 10:48
Last Modified: 05 Sep 2024 11:25
URI: http://publications.articalerewriter.com/id/eprint/1108

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