Cardiac beta-defensins upregulate with a high fat diet and influence monocyte migration

Linde, Annika and Ross, Christopher and Blecha, Frank and Lushington, Gerald H. and Melgarejo, Tonatiuh (2013) Cardiac beta-defensins upregulate with a high fat diet and influence monocyte migration. Open Journal of Internal Medicine, 03 (02). pp. 81-94. ISSN 2162-5972

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Abstract

Inflammation plays a central role in development of cardiovascular pathology, and enhanced understanding of the innate immune response will help direct novel therapeutic strategies to address heart disease. Host defense peptides (HDPs)—hereunder defensins—exhibit antimicrobial, chemotactic, tissue healing and other key biological properties. Beta-defensin expression in whole-heart-homogenate has been reported in different species, and plasma alpha-defensins have been associated with cardiovascular morbidity and mortality. Still, the role of defensins in cardiac pathophysiology remains widely undetermined. Here, we show that a subset of rat-beta-defensins (rBDs) is constitutively expressed in the myocardium, and that their gene-expression level is influenced by systemic exposure to inflammatory mediators (highfat-diet and lipopolysaccharide). Using synthetic analogues of select rBD peptides, we evaluated the antimicrobial activity of these HDPs against clinically relevant pathogens and their ability as immunoregulatory compounds. We found that an innate myocardial response that involves rBDs is activated by highfat-diet feeding in rats, and that these HDPs influence monocyte migration-findings that suggest the peptides responding to exogenous danger-signals, and act within the context of a myocardial “first-line-of-defense”.

Item Type: Article
Subjects: STM Digital Press > Medical Science
Depositing User: Unnamed user with email support@stmdigipress.com
Date Deposited: 09 Jun 2023 06:11
Last Modified: 03 Sep 2024 05:20
URI: http://publications.articalerewriter.com/id/eprint/1070

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