Studies on Anti-diarrheal Activity of Cassia sieberiana in Mice

Kelechi, Madubuike G. and Favour, Onyeacholam O. (2015) Studies on Anti-diarrheal Activity of Cassia sieberiana in Mice. Journal of Advances in Biology & Biotechnology, 3 (4). pp. 139-144. ISSN 23941081

[thumbnail of Kelechi342014JABB13810.pdf] Text
Kelechi342014JABB13810.pdf - Published Version

Download (280kB)

Abstract

Purpose: Cassia sieberiana (Fabaceae), is one plant that has been reported to possess numerous pharmacological activities. The purpose of this study is to scientifically investigate its anti-diarrheal property.

Methods: The anti-diarrheal activity of the methanol extract of Cassia sieberiana leaves was evaluated in mice following various experimental models: Castor oil – induced diarrhea, gastrointestinal motility test and castor oil – induced enteropooling. A standard anti-diarrheal agent, loperamide was used as reference.

Results: Different doses (100, 200 and 400 mg/kg, p.o.) of the extract significantly (p < 0.05) decreased the number of wet fecal droppings in the castor oil – induced diarrhea, and also inhibited the propulsion of charcoal meal plug through the gastrointestinal lumen. All doses of the extract also significantly (p < 0.05) reduced the castor oil induced enteropooling. The actions of the extract were dose – related and comparable to the actions of loperamide, the standard drug. The extract did not evoke any sign of acute toxicity in mice at the doses tested; thus it was well tolerated by the mice.

Conclusion: The results suggest that C. sieberiana possess potent anti-diarrheal effect which validates its use as a non – specific regimen for treating diarrhea in traditional medicine.

Item Type: Article
Subjects: STM Digital Press > Biological Science
Depositing User: Unnamed user with email support@stmdigipress.com
Date Deposited: 02 Sep 2024 12:40
Last Modified: 02 Sep 2024 12:40
URI: http://publications.articalerewriter.com/id/eprint/1038

Actions (login required)

View Item
View Item